Thermo Fisher Scientific TNFAIP6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, approximately 70% cross-reactivity with recombinant mouse TSG-6 and less than 2% cross-reactivity with recombinant human TSG-14 are observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

The TSG6 gene is transcribed in normal fibroblasts and activated by cytokines TNF-α and IL-1 at AP-1 and NF-IL6 promoter sites.
TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein, and the adhesion receptor CD44.
It is highly homologous to CD44, particularly in the hyaluronic acid-binding domain.
TSG-6 expression is rapidly induced by TNF-α, IL-1, and lipopolysaccharide in fibroblasts, PBMCs, synovial cells, and chondrocytes.
Presence of TSG-6 in synovial fluid suggests a potential role in rheumatoid arthritis.
TSG-6 forms a stable complex with inter-alpha-inhibitor (IαI) components and enhances its inhibitory effect on plasmin protease activity, thereby modulating inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.