Thermo Fisher Scientific Bcl-xL Recombinant Rabbit Monoclonal Antibody (042)
Recombinant rabbit monoclonal antibody specific to Mouse BCL2L1/Bcl-XL. High specificity and sensitivity with lot-to-lot consistency. Preservative-free liquid form, suitable for ELISA. Stable storage at 4°C or -20°C for long-term use.
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Applications
Tested Dilution
- ELISA: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 042 |
| Immunogen | Recombinant Mouse BCL2L1/Bcl-XL Protein (Met1–Arg212) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785887 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal-origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Mouse BCL2L1/Bcl-XL.
Target Information
BCL-XL is a member of the BCL-2 protein family. These proteins form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
BCL-XL is located at the outer mitochondrial membrane and regulates mitochondrial membrane channel (VDAC) opening, which controls membrane potential, reactive oxygen species production, and cytochrome C release — key in apoptosis induction.
Two alternatively spliced transcript variants encode distinct isoforms:
- Longer isoform: acts as an apoptotic inhibitor
- Shorter isoform: acts as an apoptotic activator
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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