Thermo Fisher Scientific TSHZ3 Polyclonal Antibody
인간 TSHZ3 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P) 및 ICC/IF에 사용 가능하며 항원 친화 크로마토그래피로 정제됨. PBS 기반 버퍼에 40% 글리세롤 포함, 4°C 단기 보관 및 -20°C 장기 보관 권장.
- 카탈로그번호
- PA552616
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TSHZ3. Recombinant protein control fragment (Product #RP-89336). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648997 |
Product Specific Information
Immunogen sequence:
TNFHAMEELV KKVTEKVAKV EEKMKEPDGK LSPPKRATPS PCSSEVGEPI KMEASSDGGF RSQENSPSPP RDGCKDGSPL AEPVENGKEL VKPLASSLSG STAIITDHP
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 88%
Target Information
The Teashirt zinc finger homeobox (TSHZ) family comprises evolutionarily conserved transcription factors. In Drosophila, they are active in specific body parts for patterning, while their function in vertebrates is less clear. In mice, TSHZ proteins show distinct expression patterns in the developing and adult brain, suggesting roles in regional identity and cell type specification.
TSHZ3 and TSHZ1 interact with FE65, an adapter protein that binds to amyloid precursor protein (APP) in neurons. Together with SET and histone deacetylases, they form a gene-silencing complex targeting caspase-4. Recent studies suggest potential involvement of TSHZ proteins in carcinogenesis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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