Thermo Fisher Scientific STAT5 Monoclonal Antibody (205)
STAT5 단클론 항체(클론 205)는 인간 STAT5 단백질을 인식하는 Mouse IgG1 형 항체로, WB 및 IHC(P) 실험에 적합합니다. 비결합형 액상 제품으로 Protein A 정제, 안정화 PBS 버퍼 포함. 세포 내 STAT5 위치 분석 및 신호전달 연구용에 최적화.
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Thermo Fisher Scientific STAT5 Monoclonal Antibody (Clone 205)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 205 |
| Immunogen | Synthetic peptide STAT5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Brain tissue
- Cellular location: Cytoplasm, nucleus
Target Information
The protein encoded by this gene belongs to the STAT family of transcription factors. In response to cytokines and growth factors, STAT proteins are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
STAT5 mediates responses to ligands such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones.
Activation of STAT5 in myeloma and lymphoma associated with TEL/JAK2 gene fusion is independent of cell stimulus and essential for tumorigenesis.
The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting an anti-apoptotic role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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