Thermo Fisher Scientific Tau Monoclonal Antibody (Tau 5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Cerebrum tissue
• Cellular location: Cytoplasm, cytosol, membrane

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus interacts with neural plasma membrane components, functioning as a linker protein between both structures.

Axonal polarity is determined by TAU/MAPT localization in the neuronal cell body. Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms are involved in stabilization.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs Tau’s microtubule-binding ability, leading to microtubule destabilization and neuronal degeneration. Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II.

Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with other central nervous system disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.