Thermo Fisher Scientific TBLR1 Polyclonal Antibody
TBLR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP 등 다양한 응용에 적합합니다. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 보관합니다. 인체 TBLR1 단백질(100–150 aa 영역)을 면역원으로 제작되었습니다.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 100 and 150 of Human TBL1-related Protein 1 (UniProt ID: Q9BZK7-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) participate in diverse transcriptional repression pathways.
N-CoR and SMRT exist in large protein complexes that recruit histone deacetylases (HDACs) to create repressive chromatin environments. HDAC3 is the primary HDAC associated with these complexes and is essential for repression.
TBLR1, a WD-40 repeat protein, also associates with N-CoR and SMRT complexes and is considered a core component, though its precise role remains to be fully elucidated.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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