Thermo Fisher Scientific Calnexin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

Calnexin, also referred to as IP90, p88, and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and assist in proper folding and assembly of polypeptides.
Calnexin associates with MHC class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It functions as a chaperone that retains incompletely or improperly folded proteins in the ER.
Soluble ER resident proteins often contain the KDEL sequence for ER retention, while integral membrane ER proteins like calnexin lack KDEL but have positively charged cytosolic residues ensuring retention.
Calnexin consists of a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.