Thermo Fisher Scientific CD68 Monoclonal Antibody (815CU17), eFluor 570, eBioscience
인간 CD68 항원에 특이적인 815CU17 단클론 항체로, eFluor 570 형광으로 결합된 제품입니다. 면역조직화학 및 면역세포화학 분석에 적합하며, 인간 시료에서 높은 특이성과 재현성을 제공합니다. 556/569 nm 형광 특성으로 TRITC 필터 사용 가능.
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Thermo Fisher Scientific CD68 Monoclonal Antibody (815CU17), eFluor 570, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 570 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 815CU17 |
| Conjugate | eFluor™ 570 |
| Excitation / Emission Max | 556 / 569 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573599 |
Additional Formats
Product Specific Information
This 815CU17 monoclonal antibody reacts with human CD68, a 110 kDa transmembrane glycoprotein belonging to the sialomucin family, related to LAMP and scavenger receptors. CD68 is mainly intracellular, localized in late endosomes, and found on myeloid-derived cells such as monocytes, macrophages, dendritic cells, neutrophils, basophils, mast cells, and certain CD34+ progenitor cells.
It may function in antigen processing or lysosomal membrane protection. Expression has also been observed in activated T cells and subsets of B lymphocytes.
This antibody does not cross-react with mouse or rat CD68.
For flow cytometric analysis of human CD68, clone eBioY1/82A is recommended.
Applications Reported: Suitable for microscopy and immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections.
Applications Tested: Tested for IHC using low or high pH antigen retrieval at ≤10 µg/mL; titration recommended for optimal assay performance.
Filter Recommendation: For eFluor® 570 conjugates, use filters capturing 570 nm emission (e.g., Excitation 545/25, 565LP, Emission 605/70). Alexa Fluor® 555 or TRITC filters are acceptable.
Excitation: 555 nm
Emission: 570 nm
Target Information
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein expressed mainly in lysosomes of monocytes and macrophages, and to a lesser extent in dendritic cells and granulocytes. It may play roles in phagocytosis, lysosomal metabolism, and cell-pathogen interactions. CD68 is expressed in tonsil interdigitating reticulum cells, histiocytic lymphoma, AML, and granulocytic sarcoma. Elevated CD68 expression is observed in CD34+ cells in various malignancies, including acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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