Thermo Fisher Scientific NUP160 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000
• Publications: -

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate
• Publications: -

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and cytoplasm. The mammalian nucleoporin (NUP)-160 is part of a hetero-oligomeric complex that includes NUP107, NUP133, NUP96, and yeast sec13p homologs.
While most of the NUP107–160 sub-complex localizes to the nuclear pore, a small fraction associates with kinetochores and spindle poles during mitosis, interacting with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107–160 complex leads to defective spindle assembly, indicating multiple cellular roles. NUP160 has also been identified as an HIV dependency factor (HDF), suggesting potential as a drug target in HIV research. Multiple isoforms of NUP160 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.