Thermo Fisher Scientific NUP107 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm.
The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and the mammalian homolog of yeast sec13p.
While most of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells, associated with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107-160 complex results in defective spindle assembly, indicating multiple functions.
NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting its potential as a drug target in HIV treatment.
Multiple isoforms of NUP107 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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