Thermo Fisher Scientific Human TMP21 Synthetic Peptide
인간 TMP21 단백질의 C-말단 19개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. 항체 PA5-20315의 블로킹 펩타이드로 사용 가능하며, 알츠하이머병 관련 γ-시크리타아제 조절 연구에 활용됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP0435
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human TMP21 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the carboxy terminus of human TMP21.
PEP-0435 can be used as a blocking peptide with polyclonal antibody PA5-20315.
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates the γ-secretase, but not the ε-secretase, cleavage activity of amyloid precursor protein.
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave amyloid precursor protein at γ- and ε-sites, potentially leading to accumulation of the Abeta product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate TMP21 may regulate this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory role.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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