Thermo Fisher Scientific Human APH1 Synthetic Peptide
인간 APH1 단백질의 N-말단 13 아미노산 서열을 기반으로 한 합성 펩타이드. APH1 항체(PA5-20317)와 함께 블로킹 펩타이드로 사용 가능. 감마-시크리타제 복합체 연구에 적합. 연구용으로만 사용.
- 카탈로그번호
- PEP0437
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the amino terminus of human APH1.
PEP-0437 can be used as a blocking peptide with polyclonal antibody PA5-20317.
Target Information
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein).
The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B), and PEN2, although other components may exist.
APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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