Thermo Fisher Scientific NBS1 Monoclonal Antibody (7E4A2)
NBS1 단백질을 인식하는 Mouse monoclonal 항체로, WB, IHC, ICC, Flow, ELISA에 적합합니다. Human 및 Rat 시료에 반응하며, Protein G로 정제된 액상 항체입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7E4A2 |
| Immunogen | Purified recombinant fragment of human NBN (aa: 467–615) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898491 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex is implicated in Nijmegen breakage syndrome, an autosomal recessive disorder characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. This highlights a molecular link between double-strand break repair and cell cycle checkpoint regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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