Thermo Fisher Scientific CaV2.1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested dilution: Not specified
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Immunohistochemistry (Paraffin) (IHC (P))

• Tested dilution: 1:15–1:50
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Product Specifications

Product Specific Information

This antibody detects endogenous levels of total CACNA1A protein.

Target Information

Voltage-dependent calcium channels mediate calcium ion entry into excitable cells and participate in various calcium-dependent processes such as muscle contraction, hormone or neurotransmitter release, and gene expression.
These channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit forms the pore and determines channel activity, while auxiliary subunits modulate it.
The alpha-1A subunit, encoded by the CACNA1A gene, is primarily expressed in neuronal tissue. Mutations in this gene are associated with familial hemiplegic migraine and episodic ataxia type 2.
Polymorphic variations due to n-repeats exist in this gene, leading to multiple transcript variants. Expansion of n-repeats in the coding region (from 4–16 to 21–28) causes spinocerebellar ataxia type 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.