Thermo Fisher Scientific Phospho-AIRE (Ser156) Polyclonal Antibody
인간 AIRE 단백질의 Ser156 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 HeLa 세포를 양성 대조군으로 추천. PBS/glycerol 완충액에 보관되며, -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Suggested Positive Control: HeLa cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of Serine156 (P-G-S(p)-Q-L) derived from Human AIRE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554084 |
Product Specific Information
A suggested positive control for Western blot is HeLa cells.
Target Information
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression.
This nuclear protein consists of 545 amino acids with an HSR domain, two PHD-type zinc fingers, and a SAND domain. It may form homodimers, homotetramers, and nuclear bodies, and interacts with transcriptional coactivators CBP and CREBBP.
Three isoforms of AIRE are reported, one of which is predicted to be a candidate for nuclear-mediated decay (NMD).
AIRE plays a key role in immune regulation and mediates E3 ubiquitin ligase activity.
Defects in AIRE are associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a rare autosomal-recessive systemic autoimmune disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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