Thermo Fisher Scientific Phospho-Progesterone Receptor (Ser400) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phospho-Progesterone Receptor (Ser400). Validated for Western blot with recommended dilution 1:500–1:1,000. Supplied unconjugated in liquid form (1 mg/mL). Suitable for research on progesterone signaling and recep...
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Applications
- Western Blot (WB): 1:500–1:1,000
- Suggested positive control: 293 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 400 (A-R-S(p)-P-R) derived from Human Progesterone Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554082 |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with pregnancy.
PR exists as a 94 kDa (Form A) or 120 kDa (Form B) protein due to alternative translation initiation sites.
- PR-B is transcriptionally active and responsible for gene activation related to endometrium maintenance and ovulation inhibition.
- PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
Upon progesterone binding, PR undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene can lead to reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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