Thermo Fisher Scientific Phospho-Amyloid Precursor Protein (Thr743) Polyclonal Antibody
Phospho-Amyloid Precursor Protein (Thr743)를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 등 다양한 종에 반응하며, APP 인산화 연구 및 알츠하이머 질환 관련 연구에 적합. -20°C 보관, 1 mg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine 743 (A-V-T(p)-P-E) derived from human Amyloid Precursor Protein (APP) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554086 |
Product Specific Information
- Suggested positive control for Western blot: COS7 cells
- Suggested positive control for IHC: Human brain tissue
- Suggested positive control for ICC/IF: HeLa cells
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1.
APP is essential for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms generated by alternative splicing.
Proteolytic cleavage by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques — a key feature in Alzheimer’s disease pathology.
Abnormal APP processing is also implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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