Thermo Fisher Scientific Phospho-ACK1 (Tyr284) Polyclonal Antibody
Phospho-ACK1 (Tyr284) 폴리클로날 항체로 인산화된 ACK1 단백질을 특이적으로 검출. Western blot 및 IHC(P) 적용 가능. Human, Mouse, Rat 반응성. 고순도 정제 및 안정한 글리세롤 보존 용액 형태.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-ACK1 (Tyr284) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNK2 (Accession Q07912), corresponding to amino acid residues around phosphorylated Tyr284. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817052 |
Product Specific Information
This antibody detects endogenous levels of ACK1 only when phosphorylated at Tyr284.
Target Information
TNK2 (ACK, activated Cdc42-associated kinase) is a non-receptor tyrosine kinase that signals downstream of Cdc42. TNK2 is implicated in tumorigenesis and metastasis, particularly in prostate cancer. It mediates CDC42-dependent cell migration via phosphorylation of BCAR1 and may play roles in synaptic function, brain development, and cancer progression. TNK2 activates AKT1 by phosphorylating Tyr-176, phosphorylates AR on Tyr-267 and Tyr-363 to enhance ARE binding, and phosphorylates WWOX and MCF2, influencing tumor growth and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.