Thermo Fisher Scientific Phospho-MEF2C (Ser396) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of MEF2C only when phosphorylated at S396.

Target Information

MEF2C is a transcription activator that binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. It controls cardiac morphogenesis and myogenesis, and is involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by regulating excitatory synapse number and synaptic transmission. Crucial for neuronal development, megakaryocyte and platelet formation, and bone marrow B lymphopoiesis. Required for B-cell survival and proliferation, efficient IgG1 antibody responses, and normal germinal center B-cell induction. May also be involved in neurogenesis and cortical architecture development. Isoform 3 and 4, lacking the repressor domain, are more active than isoform 1 and 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: PA5-105621_MEF2C_Q06413-1_Rabbit.svg, PA5-105621_MEF2C_Q06413-1_Rabbit_PDP.jpeg)