Thermo Fisher Scientific Cytokeratin 18 Polyclonal Antibody
사이토케라틴 18을 인식하는 토끼 폴리클로날 항체로, 인간·마우스·랫트 반응성. Western blot, IHC, ICC/IF에 사용 가능. 고순도(>95%) 및 항원 친화 크로마토그래피 정제. 연구용으로 세포 및 조직 내 CK18 발현 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 381–430 of Human Cytokeratin 18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2802957 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) is a low molecular weight acidic keratin that pairs with Cytokeratin 8. It is expressed in epithelial tissues of the gastrointestinal, respiratory, and urogenital tracts, as well as endocrine, exocrine, and mesothelial cells. CK18 is predominantly found in non-squamous epithelia and is expressed in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only CK8 and CK18. Mutations in the CK18 gene are associated with cryptogenic cirrhosis. Two transcript variants encoding the same protein have been identified. Cytokeratin subtype expression patterns aid in distinguishing epithelial malignancies and are valuable in tumor diagnosis, cytopathology, and flow cytometry assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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