Thermo Fisher Scientific Phospho-Cardiac Troponin I (Ser 23, Ser24) Polyclonal Antibody
Cardiac Troponin I의 Ser23/Ser24 인산화 부위를 인식하는 폴리클로날 항체로, 인간, 생쥐, 랫트 시료에서 사용 가능. Western blot에 적합하며, 내인성 인산화 단백질 검출에 유용. PBS/glycerol buffer에 보관되며 -20°C에서 안정적.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from mouse TNNI3 around the phosphorylation site of Ser23+Ser24 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817003 |
Product Specific Information
This antibody detects endogenous levels of TNNI3 only when phosphorylated at Ser23 and Ser24.
Target Information
Cardiac Troponin I (TNNI3) is a cardiac muscle–specific inhibitory protein that functions as part of the troponin complex with troponin C (TnC) and troponin T (TnT).
TnT binds to tropomyosin, forming a troponin–tropomyosin complex anchored by TnI binding to actin within thin filaments.
When calcium binds to TnC, it induces structural changes that release the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, helping to distinguish between angina and myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the TNNI3 gene can cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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