Thermo Fisher Scientific VHL Polyclonal Antibody
VHL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific VHL Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Immunocytochemistry (ICC/IF): 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human VHL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2803512 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome associated with various malignant and benign tumors. A germline mutation of the VHL gene underlies familial inheritance of the syndrome.
The encoded protein forms a complex with elongin B, elongin C, and cullin-2, possessing ubiquitin ligase E3 activity. It mediates ubiquitination and degradation of hypoxia-inducible factor (HIF), a transcription factor regulating oxygen-dependent gene expression. RNA polymerase II subunit POLR2G/RPB7 is also a reported target.
Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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