Thermo Fisher Scientific TERT Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 TERT 폴리클로날 항체. Western blot에 최적화되어 있으며, 고순도(>95%) 항원 친화 크로마토그래피로 정제됨. PBS와 50% 글리세롤 버퍼에 보관, 연구용으로만 사용 가능.
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Thermo Fisher Scientific TERT Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human TERT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2803510 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG.
The enzyme consists of a protein component with reverse transcriptase activity (encoded by the TERT gene) and an RNA component serving as a template for telomere repeat synthesis.
Telomerase expression is normally repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence. Deregulation of telomerase expression may contribute to oncogenesis.
Mouse studies suggest telomerase also participates in chromosomal repair, as de novo synthesis of telomere repeats may occur at double-stranded breaks.
Alternatively spliced variants encoding different isoforms of TERT have been identified; some full-length sequences remain undetermined. Alternative splicing at this locus is thought to regulate telomerase activity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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