Thermo Fisher Scientific TERT Polyclonal Antibody

Thermo Fisher Scientific TERT Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:1,000
Publications: -

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG.
The enzyme consists of a protein component with reverse transcriptase activity (encoded by the TERT gene) and an RNA component serving as a template for telomere repeat synthesis.

Telomerase expression is normally repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence. Deregulation of telomerase expression may contribute to oncogenesis.
Mouse studies suggest telomerase also participates in chromosomal repair, as de novo synthesis of telomere repeats may occur at double-stranded breaks.

Alternatively spliced variants encoding different isoforms of TERT have been identified; some full-length sequences remain undetermined. Alternative splicing at this locus is thought to regulate telomerase activity.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.