Thermo Fisher Scientific Slc30A8 Polyclonal Antibody
SLC30A8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 사람 시료에 반응하며, 아연 수송체 연구 및 제2형 당뇨 관련 연구에 적합. 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC30A8 (Accession Q8IWU4), corresponding to amino acid residues I179–I229 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852615 |
Product Specific Information
This antibody detects endogenous levels of total SLC30A8.
Target Information
Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans. It co-localizes with insulin in the secretory pathway granules of insulin-secreting INS-1 cells.
Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes.
Slc30A8 expression in β-cells is influenced by cytokine expression, particularly IFN-γ and IL-1β.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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