Thermo Fisher Scientific PROZ Monoclonal Antibody (OTI4A9), TrueMAB
Human PROZ 단백질에 특이적인 Mouse 단클론 항체로 Western blot에 적합합니다. Affinity chromatography로 정제된 액상 형태이며, PBS/BSA/glycerol buffer에 보존됩니다. 연구용으로만 사용 가능하며, 응고 관련 단백질 연구에 활용됩니다.
- 카탈로그번호
- TA806742
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution
- 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 115–400 of human PROZ produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PROZ (Protein Z) is a vitamin K-dependent plasma glycoprotein, approximately 62 kDa and 396 amino acids in length. It contains four domains: a gla-rich region, two EGF-like domains, and a trypsin-like domain. Although structurally related to serine proteases such as factors VII, IX, X, and protein C, PROZ lacks catalytic activity due to the absence of a key serine residue. It plays a role in the coagulation cascade by facilitating the degradation of factor Xa through protein Z-related protease inhibitor (ZPI), enhancing the reaction rate up to 1000-fold. Deficiency states have been linked to both thrombosis and bleeding tendencies, though mechanisms remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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