Thermo Fisher Scientific Tau VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1351)

Applications

ELISA

• Assay-dependent

Surface Plasmon Resonance (SPR)

• Assay-dependent

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures. Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.

Short isoforms of Tau contribute to cytoskeletal plasticity, whereas longer isoforms may stabilize it. In its hyper-phosphorylated form, Tau is the main component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease (AD) brain. Hyper-phosphorylation impairs Tau’s microtubule-binding function, leading to microtubule destabilization and neuronal degeneration in AD.

Tau is phosphorylated by multiple serine/threonine kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions associated with Alzheimer’s disease and other central nervous system disorders such as Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.