Thermo Fisher Scientific TCF2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (94%), Rat (96%), Xenopus laevis (84%), Pig (95%), Rhesus Monkey (98%), Bovine (95%).
• Positive Control: A549, A549 nuclear extract.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Hepatocyte Nuclear Factor 1 (HNF1, also known as Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1 has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.