Thermo Fisher Scientific CNTNAP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence:
  LQIDLMKKHR IRAVATQGSF NSWDWVTRYM LLYGDRVDSW TPFYQRGHNS

• Sequence homology:
  Cow: 100%
  Dog: 100%
  Guinea Pig: 100%
  Horse: 100%
  Human: 100%
  Mouse: 93%
  Rabbit: 100%
  Rat: 100%

Target Information

CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex.
The 1,384-amino acid protein, also designated p190 or CASPR (contactin-associated protein), includes:

• Extracellular domain with several putative protein-protein interaction domains
• Putative transmembrane domain
• 74-amino acid cytoplasmic domain

The architecture of its extracellular domain is similar to that of neurexins, and this protein may serve as the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.