Thermo Fisher Scientific IL-12 p40 Polyclonal Antibody
IL-12 p40 단백질을 인식하는 Rabbit Polyclonal Antibody로 Mouse와 Rat 시료에 반응. Western Blot과 IHC(Paraffin)에서 검증됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived rat IL12B recombinant protein (Position: M23–E250) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 4 mg trehalose |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746579 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells and has a broad array of biological activities.
Interleukin 12 is a disulfide-linked heterodimer composed of a 40 kDa cytokine receptor-like subunit encoded by this gene and a 35 kDa subunit encoded by IL12A.
This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cell development. It is important for maintaining sufficient memory/effector Th1 cells to mediate long-term protection against intracellular pathogens.
Overexpression of IL12B has been observed in the central nervous system of patients with multiple sclerosis (MS), suggesting its role in disease pathogenesis.
Promoter polymorphism of IL12B is associated with the severity of atopic and non-atopic asthma in children.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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