Thermo Fisher Scientific IL-12 p40 Polyclonal Antibody
인간 IL-12 p40 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 동결건조 형태로 제공되며, 재구성 시 500 µg/mL 농도. 면역세포 반응 연구에 유용.
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- pk
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Applications
- Western Blot (WB): 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human IL-12 (p40) (23–40aa IWELKKDVYVVELDWYPD) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide, 0.05 mg thimerosal |
| Storage conditions | −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746578 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells and has diverse biological activities.
Interleukin 12 is a disulfide-linked heterodimer composed of a 40 kDa receptor-like subunit (encoded by IL12B) and a 35 kDa subunit (encoded by IL12A).
It is expressed by activated macrophages and is essential for Th1 cell development and maintenance of memory/effector Th1 cells for long-term protection against intracellular pathogens.
Overexpression has been observed in the CNS of multiple sclerosis patients, suggesting a role in disease pathogenesis.
Promoter polymorphisms have been associated with asthma severity in children.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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