Thermo Fisher Scientific NOXA Monoclonal Antibody (1A2D3)
인간 NOXA 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체. Western blot 및 유세포분석(Flow cytometry)에 적합. 단백질 G 정제, 액상 형태, PBS 버퍼 및 sodium azide 포함. 세포 사멸 관련 연구에 활용 가능.
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Thermo Fisher Scientific NOXA Monoclonal Antibody (1A2D3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A2D3 |
| Immunogen | Purified recombinant fragment of human PMAIP1 (aa 1–54) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898514 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA.
A new p53 target gene, Noxa, was identified, encoding a BH3-only proapoptotic protein. Both Noxa and PUMA are transcriptional targets of p53. X-ray irradiation increases p53-dependent Noxa mRNA and protein levels.
Ectopic expression of Noxa interacts with anti-apoptotic Bcl-2 family members, resulting in activation of caspase-9. Noxa localizes to mitochondria and induces apoptosis in response to p53.
Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa are associated with impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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