Thermo Fisher Scientific POMC Monoclonal Antibody (6D2B5)
인간 POMC 단백질(aa 1-150)을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체. Western blot, ICC/IF, ELISA에 적합하며, 단백질 G 정제된 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D2B5 |
| Immunogen | Purified recombinant fragment of human POMC (aa 1–150) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898516 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The POMC gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing by prohormone convertases. It contains eight potential cleavage sites, which can yield up to ten biologically active peptides depending on tissue type and enzyme availability.
In the anterior pituitary, adrenocorticotrophin and β-lipotropin are the major end products, essential for steroidogenesis and adrenal maintenance. In other tissues such as hypothalamus, placenta, and epithelium, processing produces peptides involved in pain regulation, energy homeostasis, melanocyte stimulation, and immune modulation.
Mutations in this gene are associated with early-onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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