Thermo Fisher Scientific IL8 Monoclonal Antibody (4F1)
IL8 단백질을 표적으로 하는 Mouse monoclonal antibody(4F1)로, Human 시료에 반응. Western blot, ELISA, IP에 사용 가능. PBS buffer 내 액상 형태이며 보존제 없음. -20°C 보관, 반복 동결/해동 피해야 함.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10 µg/mL |
| ELISA (ELISA) | 10 µg/mL |
| Immunoprecipitation (IP) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F1 |
| Immunogen | IL8 (AAH13615, 21 a.a. approximately 99 a.a) full length recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor that belongs to the CXC subfamily of chemokines, and is bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor.
The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies.
IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors.
Previous nomenclature for IL-8 includes:
- Neutrophil activating protein 1 (NAP-1)
- Granulocyte chemotactic protein 1 (GCP-1)
- Monocyte-derived neutrophil-activating peptide (MONAP)
- Protein 3-10C
IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumors, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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