Thermo Fisher Scientific IL8 Monoclonal Antibody (4F1)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor that belongs to the CXC subfamily of chemokines, and is bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor.
The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies.

IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors.
Previous nomenclature for IL-8 includes:

• Neutrophil activating protein 1 (NAP-1)
• Granulocyte chemotactic protein 1 (GCP-1)
• Monocyte-derived neutrophil-activating peptide (MONAP)
• Protein 3-10C

IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumors, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.