Thermo Fisher Scientific HBEGF Monoclonal Antibody (OTI8B5), TrueMAB
인간 HBEGF 단백질(아미노산 20-208)에 특이적인 단클론 항체로, Western blot에 최적화됨. Mouse IgG1 형이며, 액상 형태로 제공. Affinity chromatography로 정제되어 높은 순도 확보. 연구용으로 EGFR 관련 세포 신호 연구에 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20-208 of human HBEGF produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HBEGF is a growth factor that mediates its effects via EGFR, ERBB2, and ERBB4. It is required for normal cardiac valve formation and heart function. HBEGF promotes smooth muscle cell proliferation and may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts but not endothelial cells. It binds EGFR with higher affinity than EGF and is a more potent mitogen for smooth muscle cells. It also acts as a diphtheria toxin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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