Thermo Fisher Scientific PRRX1 Monoclonal Antibody (OTI1E10)
PRRX1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC (Paraffin)에서 검증됨. E. coli에서 발현된 full-length human PRRX1 항원을 면역원으로 사용. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E10 |
| Immunogen | Full length human recombinant protein of PRRX1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725122 |
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species, functioning to bind DNA via a helix-turn-helix structure and playing a role in transcriptional regulation.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 acts as a transcriptional co-activator enhancing the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression by growth and differentiation factors.
Additionally, PRX1 regulates creatine kinase-M transcriptional activity, contributing to mesodermal muscle type establishment.
PRX1 exists as two alternatively spliced isoforms, PMX1-A and PMX1-B.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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