Thermo Fisher Scientific PRRX1 Monoclonal Antibody (OTI6A4)
PRRX1 단백질을 인식하는 마우스 단클론 항체로, Western blot과 파라핀 절편 면역조직화학에 적합합니다. 인간 시료에 반응하며, 액상 형태로 1 mg/mL 농도입니다. Affinity Chromatography로 정제되었고, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A4 |
| Immunogen | Full length human recombinant protein of PRRX1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725124 |
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species and functions to bind DNA via a helix-turn-helix structure, playing a role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 acts as a transcriptional co-activator enhancing serum response factor (SRF) DNA-binding activity, mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), contributing to the establishment of mesodermal muscle types.
PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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