Thermo Fisher Scientific TrxR2 Polyclonal Antibody

Thermo Fisher Scientific TrxR2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive control: HepG2
• Predicted reactivity: Mouse (80%), Rat (80%), Rhesus Monkey (97%), Guinea Pig (86%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases. Mammalian TrxRs are homologous to glutathione reductase with respect to primary structure, including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-), but distinctively possess a C-terminal extension with a catalytically active penultimate selenocysteine (SeCys) residue (-Gly-Cys-SeCys-Gly).
TrxR is a homodimeric protein containing an FAD prosthetic group, NADPH binding site, and redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to the C-terminal SeCys-containing redox center, which reduces substrates like thioredoxin.
TrxR family members (TrxR1, TrxR2, TrxR3) are 55–58 kDa proteins involved in cellular protection against oxidative stress and regulation of transcription factors and various biological processes.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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