Thermo Fisher Scientific TrxR2 Polyclonal Antibody
TrxR2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. 인간 반응성, 항원 친화 크로마토그래피 정제, 고농도 액상 형태. 세포 산화 스트레스 연구 및 TrxR2 기능 분석에 적합.
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Thermo Fisher Scientific TrxR2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 207–524 of Human TrxR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546934 |
Product Specific Information
- Recommended positive control: HepG2
- Predicted reactivity: Mouse (80%), Rat (80%), Rhesus Monkey (97%), Guinea Pig (86%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases. Mammalian TrxRs are homologous to glutathione reductase with respect to primary structure, including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-), but distinctively possess a C-terminal extension with a catalytically active penultimate selenocysteine (SeCys) residue (-Gly-Cys-SeCys-Gly).
TrxR is a homodimeric protein containing an FAD prosthetic group, NADPH binding site, and redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to the C-terminal SeCys-containing redox center, which reduces substrates like thioredoxin.
TrxR family members (TrxR1, TrxR2, TrxR3) are 55–58 kDa proteins involved in cellular protection against oxidative stress and regulation of transcription factors and various biological processes.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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