Thermo Fisher Scientific TIP60 Polyclonal Antibody
TIP60 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 Immunocytochemistry에 적합. 인간 및 생쥐 반응성, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TIP60 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 230–492 of Human TIP60 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.81 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546933 |
Product Specific Information
- Recommended positive controls: Jurkat, Jurkat nuclear extract, mouse brain, Tip60 transfected 293T lysate
- Predicted reactivity: Mouse (100%), Rat (100%), Pig (99%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TIP60 is a transcription factor originally identified as an HIV-1 TAT-interactive protein. It interacts with the viral TAT protein, leading to HTATIP polyubiquitination and degradation.
Belonging to the MYST family of histone acetyltransferases (HATs), TIP60 functions as a catalytic subunit of the NuA4 complex, which acetylates histones H4 and H2A to activate transcription of select genes.
TIP60 acts as a co-regulator of transcription factors and can either promote or suppress tumorigenesis. It plays important roles in DNA repair, apoptosis, and signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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