Thermo Fisher Scientific pro-Brain Natriuretic Peptide Monoclonal Antibody (13G12)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

13G12

Immunogen

Synthetic peptide corresponding to the N-terminal residues E(13) T S G L Q E Q R N H L Q G K(27) of human proBNP. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:pro-Brain Natriuretic Peptide,uniProtId:P16860-1,ncbiNodeId:9606,antigenRange:13-27,antigenLength:134,antigenImageFileName:MA1-20886_pro-Brain_Natriuretic_Peptide_P16860-1_House_mouse.svg,antigenImageFileNamePDP:MA1-20886_pro-Brain_Natriuretic_Peptide_P16860-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2251639

Product Specific Information

MA1-20886 detects proBNP in human samples.

Target Information

In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa signal peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.