Thermo Fisher Scientific Phospho-SNAIL (Ser246) Polyclonal Antibody
Phospho-SNAIL (Ser246) 폴리클로날 항체로, Western blot 및 IHC(파라핀 절편)에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. SNAI1 인산화 단백질 검출에 유용한 연구용 시약입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 211–260 of human SNAI1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553721 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 29 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and functions in mesoderm and neural crest formation.
SNAI1 plays a key role in tumor invasion by repressing E-cadherin and inducing epithelial–mesenchymal transition (EMT).
In human breast cancer, expression of SNAI1 and/or SNAI2 (Slug) is associated with E-cadherin repression, metastasis, tumor recurrence, and poor prognosis.
Snail 1 protein in the stroma may also serve as a potential prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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