Thermo Fisher Scientific GP130 Polyclonal Antibody
GP130 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 사용 가능. Human과 Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 안정적인 액상 형태로 4°C 또는 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | 2 publications |
| Flow Cytometry (Flow) | - | 1 publication |
| Competition Assay (CA) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 602–837 of Human CD130 (UniProt ID: P40189-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546408 |
Product Specific Information
- Recommended positive controls: HeLa, HepG2
- Predicted reactivity: Mouse (92%), Rat (92%), Dog (94%), Pig (95%), Rhesus Monkey (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM).
This protein functions as part of the cytokine receptor complex, and its activation depends on cytokine binding to their receptors.
vIL6, a protein encoded by Kaposi sarcoma-associated herpesvirus, can directly activate this protein without IL6R.
Knockout studies in mice indicate a critical role in regulating myocyte apoptosis.
Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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