Thermo Fisher Scientific HOXD11 Monoclonal Antibody (5G4)
HOXD11 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal antibody (Clone 5G4). Western blot, ICC/IF, ELISA에 사용 가능. 인체 반응성, 액상 형태, 보존제 무첨가. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5G4 |
| Immunogen | HOXD11 (NP_067015, 1–76 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MNDFDECGQS AASMYLPGCA YYVAPSDFAS KPSFLSQPSS CQMTFPYSSN LAPHVQPVRE VAFRDYGLER AKWPYR
Target Information
HOX11, also called homeobox11 or Tcl-3, is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine and proline-rich amino terminus. HOX11 is required for spleen development and cell survival. The protein binds specific DNA sequences and localizes to the nucleus, acting as a transcription activator.
The HOX11 gene is highly expressed in T-ALLs due to chromosomal translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11), leading to deregulation and activation of tumor-associated target genes. HOX11 gene translocation has been linked to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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