Thermo Fisher Scientific CDC7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 275-574 of human CDC7 (NP_001127892.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDC7,uniProtId:O00311-1,ncbiNodeId:9606,antigenRange:275-574,antigenLength:574,antigenImageFileName:PA5-109501_CDC7_O00311-1_Rabbit.svg,antigenImageFileNamePDP:PA5-109501_CDC7_O00311-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.42 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2854912

Product Specific Information

Immunogen sequence: EGSVGLSVQR SVFGERNFNI HSSISHESPA VKLMKQSKTV DVLSRKLATK KKAISTKVMN SAVMRKTASS CPASLTCDCY ATDKVCSICL SRRQQVAPRA GTPGFRAPEV LTKCPNQTTA IDMWSAGVIF LSLLSGRYPF YKASDDLTAL AQIMTIRGSR ETIQAAKTFG KSILCSKEVP AQDLRKLCER LRGMDSSTPK LTSDIQGHAS HQPAISEKTD HKASCLVQTP PGQYSGNSFK KGDSNSCEHC FDEYNTNLEG WNEVPDEAYD LLDKLLDLNP ASRITAEEAL LHPFFKDMSL

Target Information

CDC7 is a cell division cycle 7 homolog protein that is critical for the G1/S transition and is also essential for initiation of DNA replication as cell division occurs. CDC7 is expressed in many normal tissues, but the overexpression of CDC7 may be associated with neoplastic transformation for some tumors and transformed cell lines. CDC7/DBF4 kinase promotes S phase by alleviating an inhibitory activity in Mcm4 that evolved to integrate several protein kinase. CDC7 encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.