Thermo Fisher Scientific CD47 Polyclonal Antibody

Thermo Fisher Scientific CD47 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
LLFNKTKSVE FTFCNDTVVI PCFVTNMEAQ NTTEVYVKWK FKGRDIYTFD GALNKSTVPT DFSSAKIEVS QLLKGDASLK MDKSDAVSHT GNYTCEVTEL TREGETIIEL KYRVVSWFSP N

Target Information

CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein that interacts with several integrins and regulates their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, including activation of heterotrimeric G proteins. Functionally, CD47 is involved in increasing intracellular calcium concentration upon cell adhesion to the extracellular matrix.
It also acts as a receptor for the C-terminal cell binding domain of thrombospondin and plays roles in membrane transport and signal transduction. CD47 is broadly distributed across tissues and reduced on Rh erythrocytes.
CD47 serves as a ligand for CD172a (SIRP alpha), an immune inhibitory receptor on macrophages, preventing phagocytosis of CD47-positive cells. The CD47–CD172a system affects cell migration, B cell adhesion, T cell activation, chondrocyte mechanotransduction, and neuronal development, being abundant in synapse-rich regions of the brain and retina.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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