Thermo Fisher Scientific TLX Polyclonal Antibody
Rabbit polyclonal antibody targeting human TLX (NR2E1). Validated for IHC (Paraffin) with dilution 1:200–1:500. Purified via antigen affinity chromatography and supplied in PBS with 40% glycerol. Suitable for research on brain and retinal development.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NR2E1. Recombinant protein control fragment (Product #RP-103225) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791413 |
Product Specific Information
Immunogen sequence:
IPVDANTLLA VSGMNGDNTD SQKLNKIISE IQALQEVVAR FRQLRLDATE FACLKCIVTF KAVPTHSGSE LRSFRNAAAI AALQDEAQLT LNSY
Target Information
Nuclear receptor TLX (NR2E1) is a hepatocyte NF4-like receptor involved in anterior brain differentiation, retinal development, and vision. TLX regulates genes such as RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice show reduced forebrain development and increased aggression. Deletion of the TLX locus results in cerebral hypoplasia, blindness, and extreme aggression (fierce phenotype). TLX expression has been observed in mouse brain and eye, and ESTs have been isolated from normal human brain libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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