Thermo Fisher Scientific PTX3 Monoclonal Antibody (2C3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Product is supplied at 1 mL (100 µg/mL).
• Application Notes:
  • Western blot: A non-reduced sample treatment and SDS-PAGE were used. The band size is 400 kDa.
  • Flow cytometry: This antibody stains the intra- and extracellular domain of Pentraxin 3. For intracellular staining, cells were permeabilized with buffer containing Triton. Transfected cells were used as a positive control.

Target Information

Pentraxins are a protein superfamily characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor with a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of long pentraxins, which have C-terminal pentraxin domains and novel amino-terminal domains.
Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa, and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.