Thermo Fisher Scientific ENL Monoclonal Antibody (3.1.1)
ENL 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화되어 있습니다. Human 시료에 반응하며, Protein A로 정제된 액상 형태입니다. PBS(pH 7.4) 버퍼에 보존제가 포함되어 있지 않으며, 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3.1.1 |
| Immunogen | Maltose-binding fusion protein containing ENL amino acids 414–472 (Accession no. NP_005925) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene, resulting in chimeric genes that encode an N-terminal portion of HRX fused to various partner proteins.
Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to HRX in t(11;19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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