Thermo Fisher Scientific MLL Monoclonal Antibody (N4.4)

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Immunoprecipitation (IP)

2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N4.4

Immunogen

Maltose-binding fusion protein containing MLL amino acids 161-356 (Uniprot #Q03164). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HRX,uniProtId:P55200-1,ncbiNodeId:10090,antigenRange:161-356,antigenLength:3966,antigenImageFileName:34041-100UG_HRX_P55200-1_House_mouse.svg,antigenImageFileNamePDP:34041-100UG_HRX_P55200-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of Lys-4 of histone H3 (H3K4me) complex and acetylation of Lys-16 of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, and has higher activity toward H3 acetylated on Lys-9. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.