Thermo Fisher Scientific AF4 Monoclonal Antibody (C2.1.1)
AF4 단클론 항체(C2.1.1)는 인간 AF-4 단백질을 표적으로 하는 Mouse IgG1 형 항체로, Western blot에 적합합니다. 단백질 A로 정제된 액상 형태이며, PBS(pH 7.4)에 보존제로 없이 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 34042-100UG
- 판매단위
- pk
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Applications
- Western Blot (WB): 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C2.1.1 |
| Immunogen | Maltose-binding fusion protein containing AF4 amino acids 782–979 (Accession no. NP_005926) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias.
Fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor, in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors.
MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia.
The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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