Thermo Fisher Scientific GCG Monoclonal Antibody (1E2-E6)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK

Target Information

Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus.
The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogenesis, which are antagonistic effects to those of insulin action, leading to increased blood glucose levels.
Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15–20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets.
Pathological manifestations of the glucagon-type peptide residue almost exclusively with the existence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified.
Glucagon-specific antibodies are useful as cell and tumor markers in immunohistochemical techniques and as analytical tools in hormone quantification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.